VIDAS® Equine Endocrinology
Immunoassay expertise for veterinary diagnostics
VIDAS® EQUINE INSULIN and VIDAS® EQUINE ACTH help you diagnose and monitor important equine endocrinology conditions.
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Overview
THE IMPORTANCE OF ENDOCRINOLOGY IN EQUINE HEALTH
Horses are living longer – but with that comes some challenges, notably in terms of managing endocrine conditions.
Pituitary Pars Intermedia Dysfunction (PPID), also known as Cushing’s disease, and Equine Metabolic Syndrome (EMS) are two major disorders in horses which can increase risk for various complications, notably laminitis, a debilitating condition.1 These chronic conditions often evade detection in their initial stages, making early testing crucial in achieving proper management and animal care.
IMMUNOASSAY EXPERTISE FOR EQUINE ENDOCRINE DISORDERS MANAGEMENT
VIDAS® EQUINE ENDOCRINOLOGY assays support enhanced veterinary care decisions by bringing confidence based on bioMérieux’s 60+ years of clinical diagnostics expertise.
VIDAS® Equine INSULIN and VIDAS® EQUINE ACTH (Adrenocorticotropic Hormone) assays are designed for use on VIDAS® KUBE, MINI VIDAS® and VIDAS® automated immunoassay solutions. VIDAS® systems are easy to use, flexible, and scalable. Enter a world of simplicity with the unique VIDAS® single test concept:
- Performance validated on equine samples
- Fast, accurate & reproducible results
- Easy load & go solution
- Complete kit with ready-to-use reagents
VIDAS® EQUINE ACTH and VIDAS® EQUINE INSULIN offer published performance in terms of linearity and precision, with reliable results both for the initial diagnosis and for the long-term management of PPID and EMS.
Understanding PPID: A common but complex endocrine disorder
PPID is a prevalent endocrine disorder marked by hormonal imbalances caused by age-related neurodegeneration in equines including horses, ponies and donkeys, regardless of breed or sex. The condition is diagnosed in 20%-30% of equines over 15 years old.2 A progressive neurodegenerative disease, PPID compromises the function of the pituitary gland, progressively inhibiting the gland’s ability to regulate vital physiological processes deteriorates. Among the broad spectrum of clinical signs are a long, curly hair coat, delayed shedding, loss of muscle, poor immune function, and laminitis. 3
ACTH testing for PPID
Adrenocorticotropic hormone (ACTH) testing is a key component in diagnosing PPID. When veterinarians suspect PPID based on clinical signs, measuring baseline ACTH levels provides confirmation. However, it’s important to consider context and timing for testing, as the test may miss early-stage disease4 and factors including natural seasonal fluctuations, stress or illness, may impact ACTH levels.
EMS in Horses: A metabolic imbalance with serious consequences
Insulin plays a crucial role in maintaining metabolic balance in horses. 18%-27% of horses suffer from insulin dysregulation, which can be associated with EMS (Equine Metabolic Syndrome).5 Certain subsets of horses including ponies, donkeys, Arabians and mustangs are particularly susceptible. Age is also a factor in insulin regulation.
Horses with EMS may experience abnormal fat deposits, inability to lose weight and infertility. Laminitis – less frequent but very challenging – is the most critical clinical sign associated with EMS.1
Insulin testing for EMS
Insulin testing is the cornerstone for diagnosing and managing EMS because glucose measurement is rarely useful, as horses usually exhibit compensated insulin resistance and do not develop diabetes. 6 , 7
References:
1. McFarlane, D. (2011). Equine Pituitary Pars Intermedia Dysfunction. Veterinary Clinics of North America: Equine Practice, 27(1), 93–113.
2. Michigan State University Veterinary Diagnostic Laboratory, Equine Endocrinology: Pituitary Pars Intermedia Dysfunction (PPID); 19 July 2017
3. Young, A. & Berryhill, E. Pituitary Pars Intermedia Dysfunction (PPID); 23 March 2020
4. Morgan R, Keen J, McGowan C. Equine metabolic syndrome. Vet Rec. 2015;177(7):173–179.
5 J.R. Box, et. al. Insulin dysregulation in a population of Finnhorses and associated phenotypic markers of obesity; 17 June, 2020
6. Durham et al. ECEIM consensus statement on equine metabolic syndrome. J Vet Intern Med. 2019; 33: 335-349.
7. Morgan R, Keen J, McGowan C. Equine metabolic syndrome. Vet Rec. 2015;177(7):173–179.
Assays
Technical Specifications
| VIDAS® EQUINE ACTH FEATURES | |
|---|---|
| Reference | 424847 |
| Kit content | 30 tests |
| Sample Type | EDTA equine plasma |
| Time to result | Approximately 45 min |
| Shelf life | 18 months |
| Frequency of calibration | 56 days |
| VIDAS® EQUINE INSULIN FEATURES | |
|---|---|
| Reference | 424848 |
| Kit content | 30 tests |
| Sample Type | Equine serum |
| Time to result | Approximately 20 min |
| Shelf life | 18 months |
| Frequency of calibration | 56 days |