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BIOFIRE® Respiratory 2.1 (RP2.1) Panel

1 Test. 22 Targets. ~45 Minutes. 

PCR and COVID-19 go hand in hand, but the latter is no longer the predominate upper respiratory tract infection (URTI) in circulation. Help differentiate respiratory diagnoses with the help of the BIOFIRE RP2.1 Panel, a multiplex molecular test that delivers comprehensive results within about 45 minutes. 

Respiratory Testing, Elevated

The BIOFIRE RP2.1 Panel is a frontline test to help clinicians more quickly diagnose URTIs, including COVID-19, influenza, RSV, and many others. The multiplex PCR panel identifies 22 pathogen targets within a time frame that potentially facilitates better-informed diagnosis and treatment of patients. 

The BIOFIRE RP2.1 Panel can provide the essential combination of speed, accuracy, and comprehensiveness to enable a rapid, definitive identification of a pathogen. 

Answers You Need, When You Need Them

Cough, fever, runny nose, fatigue. These symptoms can be assigned to any number of respiratory infections, making diagnosis a potentially dangerous guessing game. To improve patient outcomes and therapy management, your test should give you actionable answers as quickly as possible. Here’s how our multiplex molecular test addresses that challenge.  

Identify Pathogens More Often

The BIOFIRE RP2.1 Panel has a positivity rate of 87.2% compared to 30.2% in rapid antigen tests.2

Faster Time to Results

The panel’s turnaround time for influenza and non-influenza viruses, respectively, is 1.7 hours and 1.5 hours. This compares to 7.7 hours and 13.5 hours, respectively, in standard of care.3

Improve Antimicrobial Therapy

The RP2.1 Panel has been shown to improve targeted broad-spectrum antimicrobial therapy and reduce antimicrobial duration in patients by as much as 24 hours.4

Better Co-infection Detection

Inform your treatment decisions with comprehensive results that could shed light on possible co-infections, particularly with SARS-CoV-2. 

The Respiratory Testing Menu

Discover the 22 targets on the BIOFIRE RP2.1 Panel, including 18 viruses and four bacteria commonly associated with upper respiratory tract infections. 

Overall 97.1% sensitivity and 99.3% specificity1
Sample Type: nasopharyngeal swab in transport media or saline

  • Adenovirus
  • Coronavirus 229E
  • Coronavirus HKU1
  • Coronavirus NL63
  • Coronavirus OC43
  • Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
  • Human Metapneumovirus
  • Human Rhinovirus/Enterovirus
  • Influenza A virus
  • Influenza A virus A/H1
  • Influenza A virus A/H3
  • Influenza A virus A/H1-2009
  • Influenza B virus
  • Parainfluenza virus 1
  • Parainfluenza virus 2
  • Parainfluenza virus 3
  • Parainfluenza virus 4
  • Respiratory syncytial virus


  • Bordetella parapertussis
  • Bordetella pertussis
  • Chlamydia pneumoniae
  • Mycoplasma pneumoniae


Syndromic Testing Made Simple

The BIOFIRE® FILMARRAY® Systems run syndromic infectious disease tests. One multiplex assay simultaneously tests for the most common pathogens and antimicrobial resistance genes associated with a particular syndrome.

Learn More About Systems



The BIOFIRE TORCH System uses multiplex PCR technology to simultaneously test for a comprehensive grouping of targets in about an hour. 

  • Compatible with six-panel syndromic portfolio
  • Reduced footprint provides up to six times the throughput per square foot of laboratory bench space
  • Scalable configuration allows customized throughput
  • Simplified workflow features a touchscreen interface and integrated barcode scanner
  • Data management automation includes LIS connectivity and random-access operation


The BIOFIRE 2.0 System enables simplified test ordering, faster turnaround times, and increased accuracy by minimizing manual data entry.

  • Scalable configuration allows customized throughput and efficient use of laboratory bench space
  • Offers LIS connectivity, random-access operation, and single database management of up to 8 instruments per computer

Service & Support

To order the BIOFIRE Respiratory 2.1 Panel, contact your regional sales representative or use the following contact information:


Phone: 1-801-736-6354

US Sales Extension: 1502

International Sales Extension: 1536

Product Information

BIOFIRE RP2.1 Panel42374230 Pouch Kit

1.     Based on the prospective portion of the clinical study for the BioFire® FilmArray® Respiratory 2 Panel

2.     Kitano, T. et. al., (2020) J Infect Chemother. 26 (1):82-85

3.     Rappo U., et al. J. Clin. Microbiol. JCM.00549-16.

4.     Lee BR., et. al., (2019) J Clin Virol. 110:11-16.