BIOFIRE® SPOTFIRE® System
Discover multiplex PCR testing built for the point of care (POC). The SPOTFIRE system enables clinicians to test the patient, discuss the results, and determine appropriate treatment plans during a single office visit.
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System Overview: POC Molecular Testing
The SPOTFIRE System is a small, scalable, multiplex polymerase chain reaction (PCR) platform designed to bring reliable diagnostic results to the decentralized POC clinical setting.
Here’s what the SPOTFIRE System delivers:
- Small Footprint: Requires minimal benchtop space
- Customizable Throughput: Modular system with random access allows users to run up to four tests at the same time and scale up to four modules vertically
- Ease of Use: Easy to use with an intuitive system interface and streamlined workflow
- CLIA-Waived Tests: Can be used by any healthcare professional in any healthcare setting
- Seamless Integration: Interfaces with multiple laboratory information systems (LIS), POC data management systems and middleware
BIOFIRE SPOTFIRE Reveal Video
BIOFIRE SPOTFIRE Reveal Video
How does BIOFIRE® SPOTFIRE® Work?
The SPOTFIRE System is powered by proven syndromic testing technology that’s been adapted for near-patient settings. Its ability to support CLIA-waived tests means that anybody in the lab or clinic can run each multiplex panel and deliver results within minutes.
The SPOTFIRE workflow is also designed to fit within a busy clinic setting. It only takes about two minutes to prepare the sample and reagent, allowing for a timely impact on patient management.
The Benefits of POC Molecular Testing
Your Challenge | Our Solution |
|---|---|
Variability in Symptoms Common infections often exhibit overlapping symptoms, which could make diagnosis challenging. | Syndromic Testing Identify multiple targets associated with a specific syndrome or group of symptoms. |
Lack of Diagnostic Accuracy The accuracy of respiratory diagnostic tools may vary, which could lead to serial testing, and delayed diagnoses and treatment. | PCR Technology PCR tests are highly sensitive and specific and deliver consistent results that clinicians can trust.1,2 |
Prolonged Time to Result Delays in obtaining respiratory test results may impede timely diagnosis, treatment initiation, and overall patient care. | Fast Answers The SPOTFIRE System is designed for you to deliver results and a treatment plan while the patient is still in the room. |
High Cost of Misdiagnosis Misdiagnosis could result in prolonged treatments, potentially contributing to increased healthcare expenses and patient dissatisfaction. | Confident Diagnosis Receiving accurate, comprehensive results in office may reduce the need for callbacks, follow-up visits, and additional testing.3 |
CLIA-Waived Multiplex Panels
SPOTFIRE panels are developed with patients and clinicians in mind. They identify multiple viral and bacterial targets associated with common infections within ~20 minutes or less. With one swab, clinicians can deliver comprehensive results and a clear path forward before their patients leave.
Customer Stories
Rachel Goodman, MD, El Street Pediatrics
Learn how the broad and flexible testing capabilities of the SPOTFIRE R/ST Testing Solution helped support better patient management and care.
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Technical Specifications
Technical Documents
Access Safety Data Sheets, Instructions for Use, and more on our BIOFIRE System Documents page.
System Environmental Specifications
- 15-30°C @ 15-80% relative humidity (non-condensing)
- -50–10,000 ft (-16 m–3,048 m) operating altitude
- Indoor, stationary use only
Reagent Environmental Specifications
- Room temperature storage 15-25°C
Footprint (L x W) | Weight | Touchscreen | Modularity |
8.5 in x 12.75 in (22 cm x 32.4 cm) | Control Station: 18 lbs (8.2 kg) Modules: 14 lbs (6.4 kg) each | 8 in (21.3 cm) diagonal | 1-4 modules stackable |
Additional Resources
References:
- Arnold CG, et al. Combining an antibiotic stewardship program with a 15-pathogen viral panel to reduce inappropriate antibiotic prescribing. Microbiology Spectrum 0:e02195-25
- Banerjee, D., et al (2026). Head-to-head comparison of the performance of BIOFIRE® SPOTFIRE® Respiratory/Sore Throat Panel, Cepheid Xpert® Xpress SARS-CoV-2/Flu/RSV and Cobas® SARS-CoV-2 & Influenza A/B assay for detection of respiratory viruses. Journal of Clinical Virology, 182, 105902.
- A. C. Meltzer, C. Payette, R. Heidish, et al., “Point-Of-Care Respiratory Diagnosis and Antibiotic Utilization in the Emergency Department: A Prospective Evaluation of Multiplex PCR,” Academic Emergency Medicine (2025): 1–6, https://doi.org/10.1111/acem.70156.
