A novel marker for early detection of disseminated intravascular coagulation and sepsisJuly 13, 2003
Birmingham, Royaume Uni - 13 juillet 2003. The utility of a novel diagnostic marker for the early detection of sepsis, MDA® Waveform Analysis, will be discussed at a Breakfast Symposium organized by bioMérieux® on Monday, July 14th 2003. In this symposium, entitled “DIC, Cause or Consequence of an unfavourable outcome in sepsis?”, a panel of experts will address the role of disseminated intravascular coagulation (DIC) in the pathophysiology of sepsis. The Symposium will be held from 7 a.m. to 8.15 a.m. in Hall 9 of the International Convention Center, Birmingham, UK, on the occasion of the XIXth Congress of the International Society on Thrombosis and Haemostasis (ISTH).
Early diagnosis of sepsis and its sequelae such as DIC is one of the most critical factors in determining patient outcome. Given the often rapidly progressive nature of sepsis, and the associated high mortality rate, an early and accurate diagnosis is of great clinical importance, since it may provide the opportunity to intervene therapeutically at a time when it is still possible to reverse the condition. Consequently, there is a clear need for a fast and easy-to-perform test with a high prognostic value.
The patented Waveform Analysis technology, available on the bioMérieux MDA hemostasis analyzer, may play an important role in the early and accurate diagnosis of sepsis and DIC. The fully-automated, random access MDA system performs clotting-, chromogenic- and latex-based immunoassays. For clotting assays, such as prothrombin time (PT) and activated partial thromboplastin time (aPTT), the reaction pattern can be displayed. This is called a waveform, due to its characteristic shape. The user can be automatically alerted if the sample being tested exhibits an abnormal biphasic aPTT waveform response.
Studies have shown that such an atypical aPTT waveform response has a high prevalence in critically ill patients and is a strong predictor of DIC and sepsis. In the Intensive Care Unit (ICU) setting, aPTT waveform analysis may be particularly useful in providing early warning of unsuspected developing DIC or sepsis, thereby assisting the ICU physician in timing appropriate therapeutic intervention.